Activation of Descending Antinociceptive System Produced by Intravenous Picrotoxin
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چکیده
منابع مشابه
Mechanism of cardiovascular changes produced in cats by activation of the central nervous system with picrotoxin.
The mechanism of cardiovascular changes produced by activation of the central nervous system with picrotoxin (2 mg/kg, iv) was studied in chloralose-anesthetized cats. Effects occurred in two phases. During the early phase, there were decreases in arterial blood pressure and heart rate, and in a few cats, bradyarrhythmias. These changes were transient and superceded by an increase in arterial b...
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Effects of intravenous administration of picrotoxin (PTX), a GABA(A) receptor antagonist, upon activities of wide dynamic range (WDR) neurons in the lumbar spinal cord were studied in urethane-chloralose anesthetized cats. Intravenous PTX augmented tactile evoked responses of WDR neurons, but reduced nociceptive responses dose-dependently. Spinal transection reversed the suppression of nocicept...
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The identification of specialized mechanisms in the mammalian brainstem that function to inhibit the rostral transmission of nociceptive (pain-related) information in the spinal cord led to an explosion of research into the neuroanatomical and neurochemical substrates of these antinociceptive systems. As outlined in the present paper, most attention was directed at those mechanisms in the peria...
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ژورنال
عنوان ژورنال: PAIN RESEARCH
سال: 1996
ISSN: 0915-8588,2187-4697
DOI: 10.11154/pain.11.85